A few other medicines could change the blood levels of promethazine/phenylephrine/codeine, and vice versa. Tell your Health care supplier about all medicines which you take or have just lately taken.
Will not use with some other drug that contains acetaminophen with no inquiring your health care provider or pharmacist first. Acetaminophen is in lots of nonprescription and prescription medications (including soreness/fever prescription drugs or cough-and-chilly products and solutions).
Even though less typical, one of the most significant Unintended effects of promethazine/phenylephrine/codeine are described under, together with how to proceed if they materialize.
Codeine: Narcotic analgesics, like codeine, exert their Principal consequences over the central anxious process and gastrointestinal tract. The analgesic outcomes of codeine are due to its central motion; having said that, the exact web-sites of motion haven't been identified, plus the mechanisms associated seem like rather sophisticated. Codeine resembles morphine both equally structurally and pharmacologically, but its actions on the doses of codeine utilised therapeutically are milder, with fewer sedation, respiratory despair, and gastrointestinal, urinary, and pupillary outcomes.
Examine together with your healthcare medical professional or dentist ahead of taking any of the above Whilst you or your son or daughter are making use of this drugs.
Prior to deciding to have any clinical checks, convey to the health-related physician in cost you or your son or daughter are taking this medication. The effects of some exams could be impacted by this drugs.
for the drug labels of codeine and tramadol to recommend versus their use in adolescents between 12 and eighteen years who will be obese or have circumstances which include obstructive sleep apnea or significant lung sickness, which can improve the risk of serious respiratory issues.
Anticholinergics – Concomitant use of other brokers with anticholinergic Houses really should be undertaken with warning.
Maternally toxic doses which were about seven situations the most suggested human dose of 360 mg/day, were connected to proof of bone resorption and incomplete bone ossification. Codeine did not show proof of embrytoxicity or read more fetotoxicity while in the rabbit product at doses around two situations the maximum recommended human dose of 360 mg/day based upon a entire body floor location comparison Label. Nonteratogenic consequences
Codeine is definitely the most commonly employed opioid medication in copyright. It really is utilized To ease cough and delicate to average pain but it is addictive when used in superior doses and used about a lengthy time frame. The more you use codeine, the greater your well being is afflicted.
, towards the drug labels of codeine and tramadol alerting that codeine should not be utilized to take care of suffering or cough and tramadol really should not be employed to take care of pain in kids young than 12 several years.
Very long-phrase animal scientific tests haven't been done to assess the carcinogenic probable of codeine or of promethazine, nor are there other animal or human information about carcinogenicity, mutagenicity, or impairment of fertility Using these agents.
Codeine: Dosage of codeine SHOULD NOT BE Amplified if cough fails to reply; an unresponsive cough needs to be reevaluated in 5 days or sooner for feasible fundamental pathology, for example foreign system or lessen respiratory tract condition. Codeine may well trigger or aggravate constipation.
Possibility of Misuse and Addiction. Misusing promethazine/phenylephrine/codeine can result in really serious Negative effects like coma or death. Misuse indicates getting a drugs in a means apart from how it absolutely was prescribed.